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郑健 讲师

发文时间:2017-05-05 22:30

 

郑健  讲师

研究方向:细胞生物活性物质利用、药物代谢动力学

Email: zhengjian0325@126.com

 

个人经历

2002.9-2006.7,东北林业大学生命科学学院,生命科学技术与人才培养基地,获理学学士学位

2006.9-2009.7,东北林业大学生命科学学院,细胞生物学学科,获理学硕士学位

2006.9-2008.9,哈尔滨工业大学纳米医药与生物传感器实验室,联合培养

2009.9-2013.7,东北林业大学盐碱地生物资源环境研究中心,细胞生物学学科,获博士学位

2011.11-2013.5,澳大利亚悉尼大学药学系,国家公派联合培养

2013.12-2017.1,东北林业大学林学博士后流动站(合作导师:阎秀峰教授)

2013.7-至今,东北林业大学盐碱地生物资源环境研究中心,讲师

 

主要学术论文

1.Jian Zheng, Ting Chan, Ling Zhu, Xiufeng Yan, Yang Wang*, Fanfan Zhou*. The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs). Xenobiotica. 2016, 46: 831-840.

2.Jian Zheng, Ting Chan, Florence Shin Gee Cheung, Ling Zhu, Michael Murray, Fanfan Zhou*. PDZK1 and NHERF1 regulate the function of human organic anion transporting polypeptide 1A2 (OATP1A2) by modulating its subcellular trafficking and stability. PLoS One. 2014, 9: e94712.

3.Jian Zheng, Xiuli Yue, Zhifei Dai, Yang Wang, Shaoqin Liu, Xiufeng Yan, Novel iron–polysaccharide multilayered microcapsules for controlled insulin release, Acta Biomaterialia, 2009, 5: 1499–1507.

4.Jian Zheng, Rui Zhang, Changmin Shao, Zhiwei Hu, Di Wang, Tao Yu, Xiufeng Yan, Yang Wang. Development and validation of a RP-HPLC method with fluorescence detection for simultaneous determination of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rat plasma. Journal of Chromatography B, 2012, 903: 81-87.

5.Jian Zheng, Honghong Guo, Na Guo, Wei Ma, Lijia Jing, Rui Zhang, Zhifei Dai, Xiufeng Yan, Yang Wang, Zhenyue Wang. A two-step pH-dependent liquid-liquid extraction combined with HPLC-fluorescence method for the determination of 10-hydroxycamptothecin in mouse liver tissue. Pharmaceutical Biology, 2012, 50: 954–961.

6.Shenglei Guo1, Jian Zheng1, Jing Dong, Na Guo, Lijia Jing, Xiuli Yue, Xiufeng Yan, Yang Wang, Zhifei Dai. Iron/dextran sulfate multilayered microcapsules for controlled release of 10-hydroxycamptothecin. International Journal of Biological Macromolecules, 2011, 49: 409-415.

7.Yong Liu, Changmin Shao, Bo Fan, Siyang Li, Yang Wang, Jian Zheng*. A Simple HPLC Method with Fluorescence Detection for Simultaneous Determination of 10-methoxycamptothecin and its Metabolite 10-hydroxycamptothecin in Rat Liver Tissue, 2015, 65:147-152.

8.Changmin Shao, Jian Zheng, Bo Fan, Shaman Luo, Jixiang Lin, Tao Yu, Xiufeng Yan, Yang Wang*. Tissue distribution of 10-methoxycamptothecin and its metabolite 10-hydroxycamptothecin in rats by a RP-HPLC method with fluorescence detection/UV detection. Anal Methods, 2015, 7, 7690-7696

9.Ting Chan, Jian Zheng, Ling Zhu, Thomas Grewal, Michael Murray, Fanfan Zhou*. Putative transmembrane domain 6 of the human organic anion transporting polypeptide 1A2 (OATP1A2) influences transporter substrate binding, protein trafficking, and quality control. Mol Pharm. 2015, 12(1): 111-119

10.Fanfan Zhou, Jian Zheng, Ling Zhu, Andreas Jodal, Pei H. Cui, Mark Wong, Howard Gurney, W. Bret Church, Michael Murray. Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2. The AAPS Journal, 2013, 15(4):1099-1108

11.Fei Xu, Zhen Li, Jian Zheng, Florence Shin Gee Cheung, Ting Chan, Ling Zhu, Hongxiang Zhuge, Fanfan Zhou. The inhibitory effects of the bioactive components isolated from scutellaria baicalensis on the cellular uptake mediated by the essential solute carrier transporters. Journal of Pharmaceutical Sciences, 2013, 102: 4205-4211

12.Zhen Li, Florence Shin Gee Cheung, Jian Zheng, Ting Chan, Ling Zhu, Fanfan Zhou. Interaction of the Bioactive Flavonol, Icariin, with the Essential Human Solute Carrier Transporters. Journal of Biochemical and Molecular Toxicology. 2013. doi: 10.1002/jbt.21540

13.Shenglei Guo, Na Guo, Jian Zheng, Yang Wang, Xiufeng Yan, Zhenyue Wang. Covalently attached hollow capsules resistant to etching of polar solution. Asian Journal of Chemistry, 2012, 24: 2605-2608

14.Na Guo, Zhiwei Hu, Xiaoxu Fan, Jian Zheng, Dehui Zhang, Tao Xu, Tao Yu, Yang Wang, Haiying Li. Simultaneous determination of salidroside and its aglycone metabolite p-tyrosol in rat plasma by Liquid Chromatography -Tandem Mass Spectrometry. Molecules, 2012, 17: 4733-4754.

李洋洋, 韩迪, 闫宝松, 郑健*, 阎秀峰. 不同品系猴头菇子实体中总酚含量测定, 食品研究与开发, 2017, 38(4): 123-126.

郑健, 岳秀丽, 王洋, 刘绍琴, 戴志飞. 一种基于硫酸葡聚糖铁复合物的胰岛素缓释微胶囊及其降血糖活性. 中国组织工程研究与临床康复, 2008, 12: 7045-7048.

穆立蔷, 郑健, 王洋, 刘立平. 紫椴花和果实化学成分及其地理变异. 林业科学, 2009, 45: 46-52.

李思阳, 郑健, 骆沙曼, 王洋. 10-羟基喜树碱的聚赖氨酸/海藻酸钠微胶囊的制备及其体外释药特性研究. 中草药, 2011, 42: 1724-1727.

郭宏红, 郑健, 井立佳, 李思阳, 阎秀峰, 王洋. RP-HPLC法测定小鼠血浆中10-羟基喜树碱的浓度. 中国药房, 2011, 1: 13-14.

刘佳, 郑健, 于涛. 哮喘动物模型研究进展. 中华临床医药杂志, 2010, 200: 118-119.

刘佳, 郑健, 于涛. 小鼠过敏性哮喘模型研究进展及评价.比较医学杂志, 2011, 21: 65-68.

张瑞, 刘佳, 郑健, 王少明, 张生, 王洋. UPLC法测定小鼠粪便中10-羟基喜树碱.中成药. 2013, 35(5):147-151.