徐志超 教授，博士生导师

联系方式：

E-mail: zcxu@nefu.edu.cn

电话：18610014204

地址：黑龙江省哈尔滨市香坊区和兴路26号

东北林业大学生命科学学院（新逸夫教学楼）

教育经历：

2013-09至2016-07，北京协和医学院-清华大学医学部，药用植物研究所，博士

2009-09至2012-07，吉林农业大学，食品科学与工程学院，硕士

2005-09至2009-07，齐鲁工业大学（原山东轻工业学院），食品科学与工程学院，学士

科研与学术工作经历：

2021-05至现在，东北林业大学，生命科学学院，教授

2018-07至2021-05，中国医学科学院，药用植物研究所，副研究员

2016-08至2018-06，中国医学科学院，药用植物研究所，助理研究员

2019-09至2020-09，比利时根特大学，VIB - UGent Center for Plant Systems Biology，访问学者，导师：Yves Van de Peer

研究经验和研究领域：

围绕本草基因组学研究体系，通过中药多组学揭示药用植物分子遗传学机制，系统搭建高复杂药用植物基因组解析平台，在中药活性成分合成及调控、中药合成生物学及药用植物分子育种等研究中取得一定进展。例如，以常用大宗中药材栀子为研究对象，解析栀子染色体水平基因组，揭示其药用活性成分西红花苷生物合成趋同进化机制，首次实现西红花苷类化合物的微生物细胞生产，通过分子辅助育种获得栀子优良新品种，建立“中药材遗传背景--品质形成--品种选育”研究新模式。以第一作者或通讯作者在国际权威杂志Mol Plant、New Phytol、BMC Biol、Plant J、Genomics Proteomics Bioinformatics等发表论文。文章他引1092次（Google scholar），部分研究成果入选ESI高被引及杂志TOP5高被引。

承担的主要科研项目

1国家自然科学基金委员会，面上项目，81973424，西红花苷生源途径解析及合成生物学研究，2020/01-2023/12，55万，主持

2中华人民共和国科学技术部，国家重点研发计划，2019YFC1711103，利用多组学开发DNA标志物，甄别易混、有毒中药材，2019/12-2021/12，336万，主持（课题）

3国家自然科学基金委员会，青年科学基金项目，31700264，丹参酮生物合成关键酶短链脱氢酶编码基因的克隆和功能鉴定，2018-01至2020-12，24万元，主持

4中华人民共和国科学技术部，重大新药创制科技重大专项，2019ZX09201005-006-003，中药原料及相应中成药的全程质量追溯关键技术，2019-01至2020-12，86万，主持（任务）

5中国医学科学院医学与健康科技创新工程，2017-I2M-1-009，炎性肺损伤和修复的系统生物医学研究，2017-01至2020-12，126万，岗位主持

6北京协和医学协和青年基金，2017350014，2-酮戊二酸依赖性双加氧酶催化丹参酮合成的分子机制研究，2017-04至2018-12，15万，主持

7国家自然科学基金委员会，面上项目，81874339，基于CCS策略的中成药龙胆泻肝丸基原物种鉴定研究，2019.01-2022.12，57万，参加

8国家自然科学基金委员会，面上项目，81573398，关键酶编码基因的可变剪接对丹参酮合成调控机制研究，2016.01-2019.12，54万，参加

发表学术论文（近五年）

[1] Zhichao Xu, Tianyi Xin, Dorothea Bartels, Ying Li, Wei Gu, Hui Yao, Sai Liu, Haoying Yu, Xiangdong Pu, Jianguo Zhou, Jiang Xu, Caicai Xi, Hetian Lei, Jingyuan Song*and Shilin Chen*.Genome analysis of the ancient tracheophyteSelaginella tamariscinareveals evolutionary features relevant to the acquisition of desiccation tolerance.Molecular Plant, 2018, 11: 983-994. (IF=12.084)

[2] Xiangdong Pu, Zhen Li, Ya Tian, Ranran Gao, Lijun Hao, Yating Hu, Chunnian He, Wei Sun, Meimei Xu, Reuben J. Peters, Yves Van de Peer,Zhichao Xu*,Jingyuan Song*. The honeysuckle genome provides insight into the molecular mechanism of carotenoid metabolism underlying dynamic flower coloration.New Phytologist, 2020,227(3):930-943.*Corresponding author(IF=8.512)

[3] Zhichao Xu#, Xiangdong Pu#, Ranran Gao, Olivia Costantina Demurtas, Steven J. Fleck, Michaela Richter, Chunnian He, Aijia Ji, Wei Sun, Jianqiang Kong, Kaizhi Hu, Fengming Ren, Jiejie Song, Zhe Wang, Ting Gao, Chao Xiong, Haoying Yu, Tianyi Xin, Victor A. Albert, Giovanni Giuliano*, Shilin Chen*, Jingyuan Song*. Tandem gene duplications drive divergent evolution of caffeine and crocin biosynthetic pathways in plants.BMC Biology, 2020, 18: 63. (IF=6.765)HIGHLIGHT

[4] Zhichao Xu#, Reuben J. Peters#, Jason Weirather, Hongmei Luo, Baosheng Liao, Xin Zhang, Yingjie Zhu, Aijia Ji, Bing Zhang, Songnian Hu, Kin Fai Au, Jingyuan Song*, Shilin Chen*.Full-length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues ofSalvia miltiorrhizaand tanshinone biosynthesis.Plant Journal, 2015, 82:951-961. (IF=6.141)ESI Highly Cited Paper;TOP5 most cited articles over 2016-2017 (Plant Journal)

[5] Zhichao Xu#, Ranran Gao#, Xiangdong Pu, Rong Xu, Jiyong Wang, Sihao Zheng, Yan Zeng, Jun Chen, Chunnian He, Jingyuan Song*. Comparative Genome Analysis ofScutellaria baicalensisandScutellaria barbataReveals the Evolution of Active Flavonoid Biosynthesis.Genomics Proteomics and Bioinformatics, 2020, 18(3): 230-240.

[6] Xiangdong Pu, Chunnian He, Yan Yang, Wei Wang, Kaizhi Hu,Zhichao Xu*,Jingyuan Song*.In VivoProduction of Five Crocins in the EngineeredEscherichia coli.ACS Synthetic Biology, 2020, 9, 5, 1160-1168. (IF=4.411) *Corresponding author封面文章

[7] Zhichao Xuand Jingyuan Song*.The 2-oxoglutarate-dependent dioxygenase superfamily participates in tanshinone production ofSalvia miltiorrhiza.Journal of Experimental Botany, 2017, 68 (9): 2299-2308. (IF= 5.908)

[8] Shasha Wu#, Wei Sun#,Zhichao Xu#, Junwen Zhai#, Xiaoping Li, Chengru Li, Diyang Zhang, Xiaoqian Wu, Liming Shen, Junhao Chen, Hui Ren, Xiaoyu Dai, Zhongwu Dai, Yamei Zhao, Lei Chen, Mengxia Cao, Xinyu Xie, Xuedie Liu, Donghui Peng, Jianwen Dong, Yu-Yun Hsiao, Shi-lin Chen*, Wen-Chieh Tsai*, Siren Lan*, Zhongjian Liu*. The genome sequence of star fruitAverrhoa carambola.Horticulture Research, 2020, 7: 95. (IF=5.404)#Co-one author

[9] Tianyi Xin, Yu Zhang, Xiangdong Pu, Ranran Gao,Zhichao Xu*and Jingyuan Song*. Trends in Herbgenomics.SCIENCE CHINA Life Sciences, 2019, 62(3): 288-308. (IF=4.611)*Corresponding author

[10]Tianyi Xin, Chang Su, Yulin Lin, Shuhong Wang,Zhichao Xu*, Jingyuan Song*. Precise species detection of traditional Chinese patent medicine by shotgun metagenomic sequencing.Phytomedicine,2018, 47: 40-47. (IF=4.268)*Corresponding author

[11]Zhichao Xu,Hongmei Luo, Aijia Ji, Xin Zhang, Jingyuan Song*, Shilin Chen*. Global identification of the full-length transcripts and alternative splicing related to salvianolic acid biosynthetic genes inSalvia miltiorrhiza.Frontiers in Plant Science,2016, 7:100. doi: 10.3389/fpls.2016.00100. (IF= 4.402)

[12]Ya Tian, Xiangdong Pu, Haoying Yu, Aijia Ji, Ranran Gao, Yating Hu,Zhichao Xu*,Hualei Wang*.Genome-wide characterization and analysis of bHLH transcription factors related to crocin biosynthesis inGardenia jasminoidesEllis (Rubiaceae).Biomed Research International, 2020, 2903861. (IF=2.276)*Corresponding author

[13]Yingxian Cui#,Zhichao Xu#, Xinlian Chen, Liping Nie, Liwei Wu, Yu Wang, Jingyuan Song, Hui Yao*. Genome-wide identification of abscisic acid (ABA) receptor pyrabactin resistance 1-like protein (PYL) family members and expression analysis of PYL genes in response to different concentrations of ABA stress inGlycyrrhiza uralensis.Chinese Journal of Natural Medicines, 2020, 18, 606-611. (IF=2.014)#Co-one author

[14]Zhichao Xu,Aijia Ji, Jingyuan Song*, Shilin Chen*. Genome-wide analysis of auxin response factor gene family members in medicinal model plantSalvia miltiorrhiza.Biology Open,2016, doi:10.1242/bio.017178. (IF=2.029)

[15]Zhichao Xu, Aijia Ji, Xin Zhang, Jingyuan Song, Shilin Chen(2016) Biosynthesis and regulation of active constituents in medicinal model plant,Salvia miltiorrhiza.Chinese Herbal Medicines2016, 8(1): 3-11.TOP10 most cited articles over 2016-2018 (Chinese Herbal Medicines)

[16]Haibin Xu#, Jingyuan Song#, Hongmei Luo#, Yujun Zhang, Qiushi Li, Yingjie Zhu, Jiang Xu, Ying Li, Chi Song, Bo Wang, Wei Sun, Guoan Shen, Xin Zhang, Jun Qian, Aijia Ji,Zhichao Xu, Xiang Luo, Liu He, Chuyuan Li, Chao Sun, Haixia Yan, Guanghong Cui, Xiwen Li, Xian'en Li, Jianhe Wei, Juyan Liu, Yitao Wang, Alice Hayward, David Nelson, Zemin Ning, Reuben J Peters, Xiaoquan Qi*, Shilin Chen*.Analysis of the genome sequence of the medicinal plantSalvia miltiorrhiza.Molecular Plant,2016,9(6): 949-952. (IF=12.084)

[17]Wei Sun#, Liang Leng#, Qinggang Yin#, Meimei Xu#, Mingkun Huang,Zhichao Xu, Yujun Zhang, Hui Yao, Caixia Wang, Chao Xiong, Sha Chen, Chunhong Jiang, Ning Xie, Xilong Zheng, Ying Wang, Chi Song*, Reuben J. Peters*and Shilin Chen*, The genome of the medicinal plantAndrographis paniculateprovides insight into the biosynthesis of the bioactive diterpenoid neoandrographolide.The Plant Journal, 2019, 97(5): 841-857. (IF=6.141)

[18]Taoli Liu#, Suize Yu#,Zhichao Xu, Jiantao Tan, Bin Wang, Yao-Guang Liu*, Qinlong Zhu*. Prospects and progress on crocin biosynthetic pathway and metabolic engineering.Computational and Structural Biotechnology Journal, 2020, 18: 3278-3286. (IF= 6.018)

[19]Hongmei Luo#, Jun Qian#,Zhichao Xu, Wanjing Liu, Lei Xu, Ying Li, Jiang Xu, Jianhong Zhang, Xiaolan Xu, Chang Liu, Liu He, Jianqin Li, Chao Sun, Francis Martin*, Jingyuan Song*and Shilin Chen*. TheWolfiporia cocosGenome and Transcriptome Shed Light on the Formation of its Edible and Medicinal Sclerotium.Genomics, Proteomics & Bioinformatics, 2019, Accepted. (IF =7.051)

[20]Yu Zhang,Zhichao Xu, Aijia Ji, Hongmei Luo, Jingyuan Song*. Genomic survey of bZIP transcription factor genes related to tanshinone biosynthesis inSalvia miltiorrhiza.Acta Pharmaceutica Sinica B, 2018, 8(2): 295-305. (IF=7.097)

[21]Tianyi Xin,Zhichao Xu, Jing Jia, Christine Leon, Songnian Hu, Yulin Lin, Subramanyam Ragupathy, Jingyuan Song*, Steven G. Newmaster*. Biomonitoring for traditional herbal medicinal products using DNA metabarcoding and single molecule, real-time sequencing.Acta Pharmaceutica Sinica B, 2018, 8(3): 488-497. (IF=7.097)

[22]Wei Yao#, Tianyue An#,Zhichao Xu,Libing Zhang, Han Gao, Wei Sun, Baosheng Liao, Chunhong Jiang, Zhongqiu Liu*, Lixin Duan*, Aijia Ji*. Genomic-wide identification and expression analysis of AP2/ERF transcription factors related to andrographolide biosynthesis inAndrographis paniculata,Industrial Crops and Products, 2020, 112878. (IF= 4.244)

[23]Han Gao#, Fuhuang Li#,Zhichao Xu, Chenhao Huang, Chao Xiong, Chunhong Jiang, Ning Xie, Liang Leng, Yi Zhang, Zubaida Yousaf, Xia Liu*, Wei Sun*. Genome-wide analysis of methyl jasmonate-regulated isoform expression in the medicinal plantAndrographis paniculata.Industrial Crops and Products, 2019, 135: 39-48. (IF=4.244)

[24]Ting Gao,Zhichao Xu, Xiaojun Song, Kai Huang, Ying Li, Jianhe Wei, Xunzhi Zhu, Hongwei Ren and Chao Sun*. Hybrid Sequencing of Full-Length cDNA Transcripts of the Medicinal PlantScutellaria baicalensis.International Journal of Molecular Sciences, 2019, 20(18): 4426. (IF=4.556)

[25]Jing Jia,Zhichao Xu, Tianyi Xin, Linchun Shi, Jingyuan Song*. Quality control of the traditional patent medicine Yimu Wan based on SMRT sequencing and DNA barcoding.Frontiers in Plant Science, 2017, 8: 926. (IF=4.402)

[26]Aijia Ji#, Jing Jia#,Zhichao Xu, Ying Li, Wu Bi, Fengming Ren, Chunnian He, Jie Liu, Kaizhi Hu*and Jingyuan Song*. Transcriptome-guided mining of genes involved in crocin biosynthesis.Frontiers in Plant Science, 2017, 8: 518. (IF=4.402)

[27]Yu Zhang#, Aijia Ji#,Zhichao Xu, Hongmei Luo, Jingyuan Song*. The AP2/ERF transcription factor SmERF128 positively regulates diterpenoid biosynthesis inSalvia miltiorrhiza.Plant Molecular Biology, 2019, 100(1-2): 83–93. (IF=3.302)

[28]Fengming Huang#, Jianchao Du#, Zhu Liang#,Zhichao Xu, Jiantao Xu, Yan Zhao, Yexuan Lin, Song Mei, Quan He, Jindong Zhu, Qiang Liu, Yanxu Zhang, Yuhao Qin, Wei Sun, Jingyuan Song, Shilin Chen and Chengyu Jiang*. Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues.SCIENCE CHINA Life Sciences, 2019, 62(3): 321-332. (IF=4.611)

[29]Qing Li#, Jingxian Feng#, Liang Chen,Zhichao Xu, Yingjie Zhu, Yun Wang, Ying Xiao, Junfeng Chen, Yangyun Zhou, Hexin Tan, Lei Zhang*and Wansheng Chen*. Genome-wide identification and characterization ofSalvia miltiorrhizalaccases reveal potential targets for salvianolic acid B biosynthesis.Frontiers in Plant Science, 2019, 10: 435. (IF=4.402)

[30]Liu He, Shuhua Fu,Zhichao Xu, Jun Yan, Jiang Xu, Hong Zhou, Jianguo Zhou, Xinlian Chen, Ying Li, Kin Fai Au*and Hui Yao*. Hybrid sequencing of full-length cDNA transcripts of stems and leaves inDendrobium officinale.Genes, 2017, 8(10): 257. (IF=3.759)

[31]Fengming Ren, Yingwei Wang,Zhichao Xu, Ying Li, Tianyi Xin, Jianguo Zhou, Yaodong Qi, Xueping Wei, Hui Yao, Jingyuan Song*. DNA barcoding ofCorydalis, the most taxonomically complicated genus of Papaveraceae.Ecology and Evolution, 2019, 9(4): 1934-1945. (IF=2.461)

[32]Shuhua Fu, Yingke Ma, Hui Yao,Zhichao Xu, Shilin Chen, Jingyuan Song and Kin Fai Au*. IDP-denovo:de novotranscriptome assembly and isoform annotation by hybrid sequencing.Bioinformatics,2018, 34(13): 2168-2176. (IF=5.610)

[33]Ying Li#, Jianguo Zhou#, Xinlian Chen, Yingxian Cui,Zhichao Xu, Yonghua Li, Jingyuan Song, Baozhong Liao and Hui Yao*. Gene losses and partial deletion of small single-copy regions of the chloroplast genomes of two hemiparasiticTaxillusspecies.Scientific reports, 2017, 7(1): 12834. (IF=3.998)

[34]Lipeng Nie, Yingxian Cui, Liwei Wu, Jianguo Zhou,Zhichao Xu, Yonghua Li, Xiwen Li, Yu Wang, Hui Yao*. Gene Losses and Variations in Chloroplast Genome of Parasitic PlantMacrosolenand Phylogenetic Relationships within Santalales.International Journal of Molecular Sciences, 2019, 20(22): 5812. (IF=4.556)

[35]Jianguo Zhou, Yingxian Cui, Xinlian Chen, Ying Li,Zhichao Xu, Baozhong Duan, Yonghua Li, Jingyuan Song and Hui Yao*. Complete chloroplast genomes ofPapaver rhoeasandPapaver orientale: molecular structures, comparative analysis, and phylogenetic analysis.Molecules, 2018, 23(2): 437. (IF=3.267)

[36]Yating Hu,Zhichao Xu,Ya Tian, Ranran Gao, Aijia Ji, Xiangdong Pu, Yu Wang, Xia Liu*, Jingyuan Song*. Genome-wide identification and analysis of AP2/ERF transcription factors related to camptothecin biosynthesis inCamptotheca acuminata,Chinese Journal of Natural Medicines, 2020, 18: 582-593. (IF= 2.014)

[37]Yingxian Cui, Liping Nie, Wei Sun,Zhichao Xu, Yu Wang, Jingyuan Song and Hui Yao*. Comparative and Phylogenetic Analyses of Ginger (Zingiber officinale) in the Family Zingiberaceae Based on the Complete Chloroplast Genome.Plants, 2019, 8(8): 283. (IF=2.762)

[38]Xinlian Chen, Yingxian Cui, Liping Nie, Haoyu Hu,Zhichao Xu, Wei Sun, Ting Gao, Jingyuan Song and Hui Yao*. Identification and Phylogenetic Analysis of the Complete Chloroplast Genomes of ThreeEphedraHerbs Containing Ephedrine.BioMed research international,2019: 5921725. (IF=2.276)

[39]Liping Nie, Yingxian Cui, Xinlian Chen,Zhichao Xu, Wei Sun, Yu Wang, Jingyuan Song and Hui Yao*. Complete chloroplast genome sequence of the medicinal plantArctium lappa.Genome, 2019, doi: 10.1139/gen-2019-0070. (IF=2.037)

[40]Xin Zhang,Zhichao Xu,Jiang Xu, Aijia Ji, Hongmei Luo*, Jingyuan Song, Chao Sun, Yuanlei Hu, Shilin Chen*. Selection and validation of reference genes for normalization of quantitative real-time reverse transcription PCR analysis inPoria cocos(schw.) wolf (fuling).Chinese Medicine,2016, 11(1), 1-17. (IF= 2.960)

出版著作

《本草基因组学-中药组学的发展与未来》科学出版社2016编委

《本草基因组学》全国高等医药院校规划教材科学出版社2018编委

《药用植物品质生物学》科学出版社2019编委

获得学术奖励

中草药国际通用DNA条形码鉴定体系，世界中医药学会联合会，中医药国际贡献奖科技进步奖，一等奖，2018（陈士林;宋经元;李西文;姚辉;王一涛;韩建萍;徐江;庞晓慧;孙超;石林春;孙伟;徐志超;李秋实;向丽）